1-Deoxysphinganine (m18:0) (Synonyms: 1-deoxySA, ES-285, Spisulosine) |
Catalog No.GC18609 |
1-Deoxysphinganine (m18:0) (ES-285) is an antiproliferative (antitumoral) compound of marine origin. 1-Deoxysphinganine (m18:0) inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation.
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Cas No.: 196497-48-0
Sample solution is provided at 25 µL, 10mM.
1-Deoxysphinganine is an atypical sphingolipid that lacks the C1-hydroxyl group of canonical sphinganine and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis. Plasma levels of 1-deoxysphinganine are increased in patients with hereditary sensory and autonomic neuropathy type 1 (HSAN1), an inherited neuropathy associated with serine palmitoyltransferase gene mutations, and in patients with glycogen storage disease type I (GSDI). Deoxysphingolipids, including 1-deoxysphinganine, are not converted to canonical sphingolipids or fatty acids and accumulate in cells, particularly in the mitochondria where 1-deoxysphinganine induces mitochondrial fragmentation and dysfunction. It also accumulates in LLC-PK1 cells and in mouse liver and kidney following application or administration, respectively, of the ceramide synthase inhibitor fumonisin B1 . 1-Deoxysphinganine is neurotoxic to dorsal root ganglion neurons in vitro, decreasing neurite length and inducing neurite contraction when used at a concentration 1 uM. It is cytotoxic to DU145 cells (IC50 = ~2 uM) but stimulates DNA synthesis in Swiss 3T3 cells when used at a concentration of 1 uM.
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