1-Ethyl-1-nitrosourea (hydrate) (Synonyms: ENU, Ethylnitrosourea, N-Ethyl-N-nitrosourea, N-Nitroso-N-ethylurea) |
| Catalog No.GC49470 |
A DNA alkylating agent
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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1-Ethyl-1-nitrosourea (ENU) is a DNA alkylating agent.1 It increases the concentrations of O6-ethylguanine, N7-ethylguanine, N7-ethyladenine, and N3-ethyladenine in rat brain. ENU (80 mg/kg) is teratogenic in vivo, inducing tumor formation and paw malformations in rat pups when administered to pregnant rats.2
1.Goth, R., and Rajewsky, M.F.Persistence of O6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosoureaProc. Natl. Acad. Sci. USA71(3)639-643(1974) 2.Druckrey, H., Ivankovi?, S., and Preussmann, R.Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant ratsNature210(5043)1378-1379(1966)
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