10-Cl-BBQ |
| Catalog No.GC50422 |
Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 23982-76-5
Sample solution is provided at 25 µL, 10mM.
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Potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC50 = 2.6 nM). Directly binds CD4+ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.
Punj et al (2014) Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 9 e88726 PMID:24586378 |Ehrlich et al (2016) Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 196 264 PMID:26573835
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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