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12-O-Methylcarnosic acid (Synonyms: Carnosic acid 12-methyl ether, 12-Methoxycarnosic Acid)

Catalog No.GC64008

12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM.

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12-O-Methylcarnosic acid Chemical Structure

Cas No.: 62201-71-2

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Sample solution is provided at 25 µL, 10mM.

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Background

12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2].

12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%[1]. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL[2].

[1]. Kazuya Murata, et al. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract. Phytother Res. 2013 Feb;27(2):212-7.
[2]. Zeynep Aydogmu?, et al. Constituents of Salvia Microphylla. Nat Prod Res. 2006 Jul 10;20(8):775-81.

Chemical Properties

Cas No. 62201-71-2 SDF Download SDF
Synonyms Carnosic acid 12-methyl ether, 12-Methoxycarnosic Acid
Formula C21H30O4 M.Wt 346.46
Solubility DMSO : 50 mg/mL (144.32 mM; Need ultrasonic) Storage 4°C, away from moisture and light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.8863 mL 14.4317 mL 28.8634 mL
5 mM 0.5773 mL 2.8863 mL 5.7727 mL
10 mM 0.2886 mL 1.4432 mL 2.8863 mL
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