Home>>Lipids>> Prostaglandins>>13,14-dihydro Prostaglandin E1

13,14-dihydro Prostaglandin E1 (Synonyms: PGE0, 13,14-dihydro PGE1)

Catalog No.GC41433

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.

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13,14-dihydro Prostaglandin E1 Chemical Structure

Cas No.: 19313-28-1

Size Price Stock Qty
500μg
$64.00
In stock
1mg
$121.00
In stock
5mg
$508.00
In stock
10mg
$887.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.

Chemical Properties

Cas No. 19313-28-1 SDF
Synonyms PGE0, 13,14-dihydro PGE1
Canonical SMILES O=C1[C@H](CCCCCCC(OC)=O)[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C1
Formula C20H36O5 M.Wt 356.5
Solubility DMF: >100 mg/ml (from PGE1),DMSO: >50 mg/ml (from PGE1),Ethanol: >50 mg/ml (from PGE1),PBS pH 7.2: >1.6 mg/ml (from PGE1) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.805 mL 14.0252 mL 28.0505 mL
5 mM 0.561 mL 2.805 mL 5.6101 mL
10 mM 0.2805 mL 1.4025 mL 2.805 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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