Home>>13(S),14(S)-epoxy Fluprostenol isopropyl ester

13(S),14(S)-epoxy Fluprostenol isopropyl ester (Synonyms: Epoxy Derivative 2, 13(S),14(S)epoxy Travoprost)

Catalog No.GC41894

Fluprostenol isopropyl ester is a potent F-series prostaglandin receptor agonist prodrug that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma.

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13(S),14(S)-epoxy Fluprostenol isopropyl ester Chemical Structure

Size Price Stock Qty
1mg
$158.00
In stock
5mg
$710.00
In stock
10mg
$1,261.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Fluprostenol isopropyl ester is a potent F-series prostaglandin receptor agonist prodrug that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. 13,14-epoxy Fluprostenol isopropyl ester is an impurity generated in the production of fluprostenol isopropyl ester. This product is a chiral enantiomer of the epoxide. The pharmacology of 13(S),14(S)-epoxy fluprostenol isopropyl ester has not been studied extensively to date.

Chemical Properties

Cas No. SDF
Synonyms Epoxy Derivative 2, 13(S),14(S)epoxy Travoprost
Canonical SMILES O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H]([C@@H]2C([C@@H](O)COC3=CC=CC(C(F)(F)F)=C3)O2)[C@H](O)C1
Formula C26H35F3O7 M.Wt 516.6
Solubility DMF: 30 mg/ml,DMSO: 5 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.9357 mL 9.6787 mL 19.3573 mL
5 mM 0.3871 mL 1.9357 mL 3.8715 mL
10 mM 0.1936 mL 0.9679 mL 1.9357 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for 13(S),14(S)-epoxy Fluprostenol isopropyl ester

Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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