| 13(S)-HODE Catalog No.GC19463 |
Sample solution is provided at 25 µL, 10mM.
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Purity = 98.00%
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| Cas No. | 29623-28-7 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | 13S-hydroxy-9Z,11E-octadecadienoic acid | ||
| Canonical SMILES | CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O | ||
| Formula | C18H32O3 | M.Wt | 296.5 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,[1],[2] and down regulates the expression of the IRGpIIb/IIIa receptor.[3]
Reference:
[1]. Buchanan, M.R., Haas, T.A., Lagarde, M., et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX The Journal of Biological Chemisty 260, 16056-16059 (1985).
[2]. Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis Prostaglandins 44(5), 413-429 (1992).
[3]. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid Cancer Res. 49(4), 1029-1037 (1989).