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15-deoxy-Δ-12,14-Prostaglandin J2 (Synonyms: 15-deoxy-Δ12,14-PGJ2)

Catalog No.GC13960

15-deoxy-Δ-12,14-Prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2.

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15-deoxy-Δ-12,14-Prostaglandin J2 Chemical Structure

Cas No.: 87893-55-8

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1mg
$398.00
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Sample solution is provided at 25 µL, 10mM.

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Background

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.[1],[2] 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.[1]

Reference:
[1]. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83(5), 813-819 (1995).
[2]. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83(5), 803-812 (1995).

Chemical Properties

Cas No. 87893-55-8 SDF
Synonyms 15-deoxy-Δ12,14-PGJ2
Chemical Name (E)-7-((S,Z)-5-((E)-oct-2-en-1-ylidene)-4-oxocyclopent-2-en-1-yl)hept-5-enoic acid
Canonical SMILES O=C1/C([C@H](C=C1)C/C=C/CCCC(O)=O)=C\C=C\CCCCC
Formula C20H28O3 M.Wt 316.44
Solubility DMF: >100 mg/ml (from PGD2), DMSO: >20 mg/ml, Ethanol: >75 mg/ml (from PGD2) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.1602 mL 15.8008 mL 31.6016 mL
5 mM 0.632 mL 3.1602 mL 6.3203 mL
10 mM 0.316 mL 1.5801 mL 3.1602 mL
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