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15-keto Prostaglandin F2α (Synonyms: 15-keto PGF2α)

Catalog No.GC41418

15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α.

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15-keto Prostaglandin F2α Chemical Structure

Cas No.: 35850-13-6

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α. in the 15-hydroxy PGDH pathway. It is one of the critical components in the goldfish and Atlantic salmon postovulatory pheromone. [1] [2] 15-keto PGF2α stimulates the male goldfish and salmon olfactory receptors with detection thresholds of 10-12 and 10-8 M, respectively. [1] [2] 15-keto PGF2α is 10-fold less active than PGF2α in decreasing rabbit intraocular pressure.[3]

Reference:
[1]. Sorensen, P.W., Hara, T.J., Goetz, F.W., et al. F prostaglandins function as potent olfactory stimulants that comprise the postovulatory female sex pheromone in goldfish. Biol. Reprod. 39(5), 1039-1050 (1988).
[2]. Moore, A., and Waring, C.P. Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARR. J. Exp. Biol. 199(Pt 10), 2307-2316 (1996).
[3]. Woodward, D.F., Williams, L.S., and Chen, J. Marked differential effects of prostanoid metabolites on rabbit intraocular pressure. Ophthalmic Res. 21(6), 428-435 (1989).

Chemical Properties

Cas No. 35850-13-6 SDF
Synonyms 15-keto PGF2α
Chemical Name 9α,11α-dihydroxy-15-oxo-prosta-5Z,13E-dien-1-oic acid
Canonical SMILES O[C@H]1[C@H](/C=C/C(CCCCC)=O)[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1
Formula C20H32O5 M.Wt 352.5
Solubility 100 mg/ml (from PGF2a) in DMF, 100 mg/ml (from PGF2a) in DMSO, 100 mg/ml (from PGF2a) in Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.8369 mL 14.1844 mL 28.3688 mL
5 mM 0.5674 mL 2.8369 mL 5.6738 mL
10 mM 0.2837 mL 1.4184 mL 2.8369 mL
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