(±)17-HDHA (Synonyms: 17-hydroxy Docosahexaenoic Acid, 17-hydroxy DHA, (±)17-HDoHE) |
| Catalog No.GC41197 |
(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro.
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Cas No.: 90780-52-2
Sample solution is provided at 25 µL, 10mM.
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(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 µM, respectively. (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
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