2,3,7,8-Tetrachlorodibenzo-p-dioxin |
| Catalog No.GC90818 |
A toxicant and an agonist of AhR
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1746-01-6
Sample solution is provided at 25 µL, 10mM.
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2,3,7,8-Tetrachlorodibenzo-p-dioxin is a toxicant and an agonist of the aryl drocarbon receptor (AhR; ED50 = 0.2 nmol/kg in a reporter assay using chicken embryos).1 It also induces AhR ubiquitination and degradation in Hepa-1c1c7 hepatic cells when used at a concentration of 1 nM.2 Oral administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (0.1 mg/kg) increases mortality and induces severe liver necrosis, tmic atrop, and cell depletion in lymphoid organs in rats.3 It does not induce hepatomegaly or reduce tmus weight and lymphocyte number but does increase immune cell infiltration into the lungs in AhR knockout mice when administered at a dose of 2 mg/kg.4
| Cas No. | 1746-01-6 | SDF | |
| Formula | C12H4Cl4O2 | M.Wt | 322 |
| Solubility | Chloroform: Slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1056 mL | 15.528 mL | 31.0559 mL |
| 5 mM | 0.6211 mL | 3.1056 mL | 6.2112 mL |
| 10 mM | 0.3106 mL | 1.5528 mL | 3.1056 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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