2',3'-cGAMP (Synonyms: 2'-3'-cyclic GMP-AMP) |
Catalog No.GC19989 |
2',3'-cGAMP is a specific STING receptor agonist. Its mechanism of action is mainly to activate the STING signaling pathway and promote the production of interferon and inflammatory factors. The Kd value of 2',3'-cGAMP binding to STING is 3.79 nM.
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Cas No.: 1441190-66-4
Sample solution is provided at 25 µL, 10mM.
2',3'-cGAMP is a specific agonist of the STING receptor, and its mechanism of action primarily involves activating the STING signaling pathway, promoting the production of interferons and inflammatory cytokines. 2',3'-cGAMP plays an important role in the innate immune pathway of mammals, responsible for the surveillance of cytoplasmic DNA. The Kd value of 2',3'-cGAMP binding to STING is 3.79 nM[1]. 2',3'-cGAMP is commonly used in research on immune regulation, antiviral immunity, and cancer treatment.
In vitro, 2',3'-cGAMP (2.2, 4.4, 8.75, 17, 35 μM) treatment of PC 3 cells for 48 hours has an IC50 value of 11.46 μM[2]. Treating the PC 3 cell line with 2',3'-cGAMP (4 µg/ml) for 10 minutes activates STING[3].
In vivo, 10 μg of 2',3'-cGAMP is as effective as 200 μg of PD-L1 antibody in combating melanoma in C57 BL/6 mice. Titration experiments show that 2',3'-cGAMP enhances the antitumor effect of the PD-L1 antibody in a dose-dependent manner[4].
References:
[1] Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35.
[2] Rezaei M .09-P53. Docetaxel Enhances the Expression of STING Protein in PC3 Prostate Cancer Cells, and cGAMP Attenuates This Effect[C]. Benchmarking an Artificial Intelligence Method for Fast Diagnosis of Rare Genetic Disease.2020.
[3] Hannes S , Karlowitz R , Wijk S J L V .The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells[J].Cell Death & Disease.2024.
[4] Wang, H. et al. cGAS is essential for the antitumor effect of immune checkpoint blockade. Proc. Natl Acad. Sci. USA 114, 1637–1642 (2017).
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