2-MPMDQ |
| Catalog No.GC16412 |
α1-adrenoceptor antagonist,potent and selective
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 149847-77-8
Sample solution is provided at 25 µL, 10mM.
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2-MPMDQ is a potent and selective antagonist of α1-adrenoceptor [1].
α1-adrenoceptor is a G protein-coupled receptor and mediates noradrenaline and adrenaline signal in the central and peripheral nervous systems. Also, α1-adrenoceptor mediates smooth muscle contraction.
2-MPMDQ is a potent and selective α1-adrenoceptor antagonist. In spontaneously hypertensive rats, 2-MPMDQ showed antihypertensive activity [1].
Reference:
[1]. Chern JW, Tao PL, Yen MH, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem, 1993, 36(15): 2196-2207.
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