21-Deoxycortisone (Synonyms: 21-Desoxycortisone, NSC 38722) |
| Catalog No.GC52083 |
A corticosteroid metabolite of 11-keto progesterone
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1882-82-2
Sample solution is provided at 25 µL, 10mM.
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21-Deoxycortisone is a corticosteroid metabolite of 11-keto progesterone.1 It is formed from 11-keto progesterone by the cytochrome P450 (CYP) isoform CYP17A1, but can also be produced via oxidation of 21-deoxycortisol by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Levels of 21-deoxycortisone are increased in patients with congenital adrenal hyperplasia, an inborn error of metabolism characterized by a deficiency in 21-hydroxylase.2
1.van Rooyen, D., Yadav, R., Scott, E.E., et al.CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathwayJ. Steroid Biochem. Mol. Biol.199105614(2020) 2.Saisho, S., Shimozawa, K., and Yata, J.Changes of several adrenal δ4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiencyHorm. Res.33(1)27-34(1990)
| Cas No. | 1882-82-2 | SDF | |
| Synonyms | 21-Desoxycortisone, NSC 38722 | ||
| Canonical SMILES | C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4(C(CC3)=CC(CC4)=O)C | ||
| Formula | C21H28O4 | M.Wt | 344.5 |
| Solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9028 mL | 14.5138 mL | 29.0276 mL |
| 5 mM | 0.5806 mL | 2.9028 mL | 5.8055 mL |
| 10 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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