25G-NBOMe (hydrochloride) |
Catalog No.GC42100 |
A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1797132-54-7
Sample solution is provided at 25 µL, 10mM.
A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances. [1][2] 25G-NBOMe (hydrochloride) is a derivative of 2C-G, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. [3] While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the 5-HT2A serotonin receptor.[4][5] This product is intended for research and forensic applications.
Reference:
[1]. Moya, P.R., Berg, K.A., Gutiérrez-Hernandez, M.A., et al. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. Journal of Pharmacology and Experimental Therapeutics 321, 1054-1061 (2007).
[2]. Meyer, M.R., and Maurer, H.H. Metabolism of designer drugs of abuse: An updated review. Curr. Drug Metab. 11(5), 468-482 (2010).
[3]. Zuba, D., and Sekula, K. Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Test.Anal. (2012).
[4]. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe3396.51 and Phe3406.52 with superpotent N-benzyl phenethylamine agonists. Mol. Pharm. 70(6), 1956-1965 (2006).
[5]. Ettrup, A., Palner, M., Gillings, N., et al. Radiosysnthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. J.Nuclear Med. 51(11), 1763-1770 (2010).
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