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3-hydroxy Phenazepam (Synonyms: 3-hydroxy Fenazepam)

Catalog No.GC42284

Phenazepam is an anxiolytic and hypnotic sedative.

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3-hydroxy Phenazepam Chemical Structure

Cas No.: 70030-11-4

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10mg
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Phenazepam is an anxiolytic and hypnotic sedative.[1]  3-hydroxy Phenazepam is a major metabolite of phenazepam. [2] [3] There are significant differences in the rate of phenazepam metabolism in different species, so that 3-hydroxy phenazepam can be detected shortly after oral administration of the parent compound in cats, rats, and dogs but not in humans.[3]  The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications. This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.

Reference:
[1]. Molodavkin, G.M., Voronina, T.A., Chernyavskaya, L.I., et al. Pharmacological activity of phenazepam and flunitrazepam in ultralow doses. Bulletin of Experimental Biology and Medicine 135, 39-41 (2003).
[2]. Maskell, P.D., De Paoli, G., Seetohul, L.N., et al. Phenazepam: The drug that came in from the cold. J.Forensic Leg.Med. 19(3), 122-125 (2012).
[3]. Zherdev, V.P., Caccia, S., Garatini, S., et al. Species differences in phenazepam kinetics and metabolism. European Journal of Drug Metabolism and Pharmacokinetics 7(3), 191-196 (1982).

Chemical Properties

Cas No. 70030-11-4 SDF
Synonyms 3-hydroxy Fenazepam
Chemical Name 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Canonical SMILES BrC1=CC(C(C2=CC=CC=C2Cl)=NC(O)C(N3)=O)=C3C=C1
Formula C15H10BrClN2O2 M.Wt 365.6
Solubility 10mg/mL in DMSO, 15mg/mL in DMF, 0.2mg/mL in Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.7352 mL 13.6761 mL 27.3523 mL
5 mM 0.547 mL 2.7352 mL 5.4705 mL
10 mM 0.2735 mL 1.3676 mL 2.7352 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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