3-hydroxy Phenazepam (Synonyms: 3-hydroxy Fenazepam) |
Catalog No.GC42284 |
Phenazepam is an anxiolytic and hypnotic sedative.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70030-11-4
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Phenazepam is an anxiolytic and hypnotic sedative.[1] 3-hydroxy Phenazepam is a major metabolite of phenazepam. [2] [3] There are significant differences in the rate of phenazepam metabolism in different species, so that 3-hydroxy phenazepam can be detected shortly after oral administration of the parent compound in cats, rats, and dogs but not in humans.[3] The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications. This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
Reference:
[1]. Molodavkin, G.M., Voronina, T.A., Chernyavskaya, L.I., et al. Pharmacological activity of phenazepam and flunitrazepam in ultralow doses. Bulletin of Experimental Biology and Medicine 135, 39-41 (2003).
[2]. Maskell, P.D., De Paoli, G., Seetohul, L.N., et al. Phenazepam: The drug that came in from the cold. J.Forensic Leg.Med. 19(3), 122-125 (2012).
[3]. Zherdev, V.P., Caccia, S., Garatini, S., et al. Species differences in phenazepam kinetics and metabolism. European Journal of Drug Metabolism and Pharmacokinetics 7(3), 191-196 (1982).
Cas No. | 70030-11-4 | SDF | |
Synonyms | 3-hydroxy Fenazepam | ||
Chemical Name | 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one | ||
Canonical SMILES | BrC1=CC(C(C2=CC=CC=C2Cl)=NC(O)C(N3)=O)=C3C=C1 | ||
Formula | C15H10BrClN2O2 | M.Wt | 365.6 |
Solubility | 10mg/mL in DMSO, 15mg/mL in DMF, 0.2mg/mL in Ethanol | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.7352 mL | 13.6761 mL | 27.3523 mL |
5 mM | 0.547 mL | 2.7352 mL | 5.4705 mL |
10 mM | 0.2735 mL | 1.3676 mL | 2.7352 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 12 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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