Home>>3-Mercaptopicolinic Acid (hydrochloride)

3-Mercaptopicolinic Acid (hydrochloride) (Synonyms: SKF 34288)

Catalog No.GC42300

3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis.

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3-Mercaptopicolinic Acid (hydrochloride) Chemical Structure

Cas No.: 320386-54-7

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100mg
$49.00
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250mg
$117.00
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500mg
$225.00
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1g
$398.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.[1][2][3]

Reference:
[1]. DiTullio, N.W., Berkoff, C.E., Blank, B., et al. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem. J. 138(3), 387-394 (1974).
[2]. Robinson, B.H., and Oei, J. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase. FEBS Lett. 58(1), 12-15 (1975).
[3]. Hidalgo, J., Latorre, P., Carrodeguas, J.A., et al. Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-mercaptopicolinic acid and novel inhibitors. PLoS One 11(7), e0159002 (2016).

Chemical Properties

Cas No. 320386-54-7 SDF
Synonyms SKF 34288
Chemical Name 3-mercapto-2-pyridinecarboxylic acid, monohydrochloride
Canonical SMILES SC1=C(C(O)=O)N=CC=C1.Cl
Formula C6H5NO2S • HCl M.Wt 191.6
Solubility 0.2mg/mL in PBS, pH 7.2 Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.2192 mL 26.096 mL 52.1921 mL
5 mM 1.0438 mL 5.2192 mL 10.4384 mL
10 mM 0.5219 mL 2.6096 mL 5.2192 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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