3'3'-cGAMP (sodium salt) (Synonyms: AdenosineGuanosine 3',3'-cyclic monophosphate, 3',3'-Cyclic GMP-AMP, c-GpAp) |
| Catalog No.GC42245 |
3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP shows weaker binding to the adapter protein stimulator of interferon genes (STING; Kd = 1.04 µM) than 2'2'-cGAMP and 2'3'-cGAMP but has similar binding affinity to 3'2'-cGAMP (Kd = 1.61 µM) and cyclic di-GMP . 3'3'-cGAMP induces IFN-β mRNA expression in L929 cells (EC50 = 40.5 nM).
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