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3'-Deoxyuridine-5'-triphosphate (Synonyms: 3'-dUTP)

Catalog No.GC60023

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II.

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3'-Deoxyuridine-5'-triphosphate Chemical Structure

Cas No.: 69199-40-2

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1mg
$2,039.00
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Sample solution is provided at 25 µL, 10mM.

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Background

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1].

[1]. M Saneyoshi, et al. Inhibitory Effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.

Chemical Properties

Cas No. 69199-40-2 SDF
Synonyms 3'-dUTP
Canonical SMILES O[C@@H]([C@H](N1C(NC(C=C1)=O)=O)O2)C[C@H]2COP(O)(OP(O)(OP(O)(O)=O)=O)=O
Formula C9H15N2O14P3 M.Wt 468.14
Solubility Storage
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1361 mL 10.6806 mL 21.3611 mL
5 mM 0.4272 mL 2.1361 mL 4.2722 mL
10 mM 0.2136 mL 1.0681 mL 2.1361 mL
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