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4,5,6,7-Tetrabromobenzimidazole (Synonyms: Casein Kinase II Inhibitor XII,TBBz)

Catalog No.GC16960

4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor.

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4,5,6,7-Tetrabromobenzimidazole Chemical Structure

Cas No.: 577779-57-8

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25mg
$239.00
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250mg
$1,669.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Ki: 0.5-1 μM

4,5,6,7-Tetrabromobenzimidazole is a CK2 inhibitor.

Casein kinase 2 (CK2), a constitutive protein kinase involved in many signal transduction pathways, is known to be able to negatively regulate apoptosis, and its activity is increased in various proliferating tissues and tumors.

In vitro: Previous study found that like the reported 4,5,6,7-tetrabromobenzotriazole (TBBt), the structurally related 4,5,6,7-tetrabromobenzimidazole (TBBz) was a selective ATP-competitive inhibitor of protein kinase CK2 from various sources including yeast, rat liver, Neurospora crassa and Candida tropicalis, with K(i) values in the range 0.5-1 μM. TBBz was found to virtually inactive vs. PKA, PKC, and a very weak inhibitor of protein kinase CK1. TBBt was noted to be a more effective inhibitor of PK60S than of yeast CK2; by contrast, TBBz was a relatively feeble inhibitor of PK60S, thus more selective than TBBt vs. CK2 in yeast cells. Therefore, similar to TBBt, TBBz could be regarded as an additional lead compound for development of more potent inhibitors of CK2 [1].

In vivo: Up to now, therer is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Zien, P. ,Bretner, M.,Zastapilo, K., et al. Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources. Biochemical and Biophysical Research Communications 306(1), 129-133 (2003).

Chemical Properties

Cas No. 577779-57-8 SDF
Synonyms Casein Kinase II Inhibitor XII,TBBz
Chemical Name 4,​5,​6,​7-​tetrabromo-1H-​benzimidazole
Canonical SMILES BrC1=C2C(N=CN2)=C(Br)C(Br)=C1Br
Formula C7H2Br4N2 M.Wt 433.7
Solubility DMSO: Soluble,Ethanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3057 mL 11.5287 mL 23.0574 mL
5 mM 0.4611 mL 2.3057 mL 4.6115 mL
10 mM 0.2306 mL 1.1529 mL 2.3057 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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