4,9-Anhydrotetrodotoxin (Synonyms: 4,9-anhydro-TTX) |
| Catalog No.GC42327 |
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes).
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Cas No.: 13072-89-4
Sample solution is provided at 25 µL, 10mM.
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4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]
Reference:
[1]. Rosker, C., Lohberger, B., Hofer, D., et al. The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. American Journal of Physiology.Cell Physiology 293(2), C783-C789 (2007).
[2]. Teramoto, N., and Yotsu-Yamashita, M. Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects. Mar.Drugs 13(2), 984-995 (2015).
[3]. Moczydlowski, E.G. The molecular mystique of tetrodotoxin. Toxicon 63, 165-183 (2013).
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