4-Chlorophenylguanidine hydrochloride |
| Catalog No.GC13337 |
Urokinase inhibitor, potent and specific
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14279-91-5
Sample solution is provided at 25 µL, 10mM.
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4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].
Urokinase is a serine protease. Its primary physiological substrate is plasminogen, which is an inactive form of plasmin. Urokinase plays an important role in vascular diseases and cancer.
4-Chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with Ki value of 6.07 μM and 120 μM, respectively [1].
Reference:
[1]. Yang H, Henkin J, Kim KH, et al. Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem, 1990, 33(11): 2956-2961.
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