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4-Vinylphenol (10%w/w in propylene glycol)

Catalog No.GC60525

4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.

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4-Vinylphenol (10%w/w in propylene glycol) Chemical Structure

Cas No.: 2628-17-3

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500mg
$46.00
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Sample solution is provided at 25 µL, 10mM.

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Background

4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo[1].

4-Vinylphenol (12.5-200 &#181g/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 &#181g/mL[1]. 4-Vinylphenol (0.15 or 0.3 &#181g/mL; 3 days) reduces sphere?formation and vimentin expression on CSCs in breast cancer[1]. 4-Vinylphenol (50, 100 &#181g/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells[1]. 4-Vinylphenol (100 &#181g/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis[1].

[1]. Leung HW, et al. The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells. Cancer Chemother Pharmacol. 2018 Aug;82(2):185-197.

Chemical Properties

Cas No. 2628-17-3 SDF
Canonical SMILES OC1=CC=C(C=C)C=C1
Formula C8H8O M.Wt 120.15
Solubility Storage -20°C, stored under nitrogen
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 8.3229 mL 41.6146 mL 83.2293 mL
5 mM 1.6646 mL 8.3229 mL 16.6459 mL
10 mM 0.8323 mL 4.1615 mL 8.3229 mL
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