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48740 RP (RP-55778) (Synonyms: RP-55778)

Catalog No.GC31917

48740 RP (RP-55778) (RP-55778) is a platelet-activating factor (PAF) antagonist.

Products are for research use only. Not for human use. We do not sell to patients.

48740 RP (RP-55778) Chemical Structure

Cas No.: 93363-11-2

Size Price Stock Qty
1mg
$690.00
In stock
5mg
$1,105.00
In stock
10mg
$1,767.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

Animal experiment:

Guinea pigs of both sexes weighing 300 to 500 g are used for the determination of free lung cell responses and histopathologic examination. Male hamsters, weighing 100 g, are used for capillary permeability determinations. Guinea pigs are pretreated with an intraperitoneal injection of 48740 RP at 20 mg/kg in saline 1 h before exposure to lipopolysaccharide (LPS) and immediately thereafter. Groups of hamsters (n=6) are treated immediately before aerosol exposure, immediately after, and 3 h afterwards[1].

References:

[1]. Rylander R, et al. Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). Int Arch Allergy Appl Immunol. 1988;86(3):303-7.

Background

48740 RP is a platelet-activating factor (PAF) antagonist.

48740 RP is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability[1].

[1]. Rylander R, et al. Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). Int Arch Allergy Appl Immunol. 1988;86(3):303-7.

Chemical Properties

Cas No. 93363-11-2 SDF
Synonyms RP-55778
Canonical SMILES O=C(C(C=C1)=C2N1C(C3=CC=CN=C3)SC2)N
Formula C12H11N3OS M.Wt 245.3
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.0766 mL 20.3832 mL 40.7664 mL
5 mM 0.8153 mL 4.0766 mL 8.1533 mL
10 mM 0.4077 mL 2.0383 mL 4.0766 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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