4α-Phorbol 12-myristate 13-acetate (Synonyms: 4α-PMA) |
| Catalog No.GC18535 |
4α-Phorbol 12-myristate 13-acetate is an inactive form of TPA, and is used as a negative control for TPA-activated events.
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Cas No.: 63597-44-4
Sample solution is provided at 25 µL, 10mM.
Phorbol 12-myristate 13-acetate is a phorbol ester that is commonly used to activate certain types of PKC, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. 4α-PMA is a structural analog of PMA that does not activate PKC. It is used as a negative control for PMA signaling through PKC.
References:
[1]. Blumberg, P.M. Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads Memorial Award Lecture Cancer Research 48(1), 1-8 (1988).
[2]. Fischer, S.M., Patrick, K.E., Lee, M.L., et al. 4β- and 4α-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms Cancer Res. 51(3), 850-856 (1991).
[3]. Savage, M.J., Trusko, S.P., Howland, D.S., et al. Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester Journal of Neuroscience 18(5), 1743-1752 (1998).
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