Home>>Signaling Pathways>> Proteases>> Drug Metabolite>>5,6-dihydro-5-Fluorouracil

5,6-dihydro-5-Fluorouracil (Synonyms: 5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-Fluoro-5,6-dihydrouracil, 5-FUH2)

Catalog No.GC18542

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).

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5,6-dihydro-5-Fluorouracil Chemical Structure

Cas No.: 696-06-0

Size Price Stock Qty
5mg
$121.00
In stock
10mg
$226.00
In stock
25mg
$535.00
In stock
50mg
$1,007.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 uM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).

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