5-hme-CTP |
| Catalog No.GB20158 |
5-hme-CTP is a modified cytidine triphosphate with a hydroxymethyl group at the 5-carbon position. It can be used to replace unmodified mRNA and enhance the stability and functionality of RNA.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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5-hme-CTP is a modified cytidine triphosphate with a hydroxymethyl group at the 5-carbon position. It can be used to replace unmodified mRNA and enhance the stability and functionality of RNA[1]. The mRNA modification function of 5-hme-CTP has a wide range of applications in gene expression research, RNA drug development and gene therapy[2]. 5-hme-CTP can reduce the innate immune response of human and other mammalian cells[3, 4].
References:
[1] Fu L, Guerrero C R, Zhong N, et al. Tet-mediated formation of 5-hydroxymethylcytosine in RNA[J]. Journal of the American Chemical Society, 2014, 136(33): 11582-11585.
[2] Kuszczynska A, Bors M, Podskoczyj K, et al. Chemistry of installing epitranscriptomic 5-modified cytidines in RNA oligomers[J]. Organic & Biomolecular Chemistry, 2024, 22(36): 7271-7286.
[3] Lu M, Xue M, Wang H T, et al. Nonsegmented negative-sense RNA viruses utilize N 6-methyladenosine (m6A) as a common strategy to evade host innate immunity[J]. Journal of virology, 2021, 95(9): 10.1128/jvi. 01939-20.
[4] Cui L, Ma R, Cai J, et al. RNA modifications: importance in immune cell biology and related diseases[J]. Signal transduction and targeted therapy, 2022, 7(1): 334.
| Cas No. | SDF | ||
| Formula | C10H18N3O15P3 (free acid) | M.Wt | 513.1 |
| Solubility | Storage | Store at -20°C or below | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.9489 mL | 9.7447 mL | 19.4894 mL |
| 5 mM | 0.3898 mL | 1.9489 mL | 3.8979 mL |
| 10 mM | 0.1949 mL | 0.9745 mL | 1.9489 mL |
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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