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5-hydroxypyrazine-2-carboxylic acid Catalog No.GC15424

Metabolite of pyrazinamide (PZA)

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100mg
$104.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Chemical Properties

Cas No. 34604-60-9 SDF
Chemical Name 5-hydroxypyrazine-2-carboxylic acid
Canonical SMILES OC1=NC=C(C(O)=O)N=C1
Formula C5H4N2O3 M.Wt 140.1
Solubility ≥7 mg/mL in DMSO, <2.84 mg/mL in EtOH, ≥7.63 mg/mL in H2O Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

5-Hydroxypyrazine-2-Carboxylic Acid, a metabolite of anti-tuberculosis drug pyrazinamide (PZA).

References:
[1]. Huq, Fazlul; Hossain, Zahed. Molecular modelling analysis of the metabolism of pyrazinamide. Journal of Pharmacology and Toxicology (2006), 1(6), 505-515.
[2]. Mehmedagic, Aida; Verite, Philippe; Menager, Sabine et al. Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats. Biopharmaceutics & Drug Disposition (2002), 23(5), 191-195.