5-Methyl-UTP |
| Catalog No.GB20117 |
5-methyl-UTP is a modified nucleoside triphosphate that can significantly affect the structure and function of RNA and plays an important role in biological systems.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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5-methyl-UTP is a modified nucleoside triphosphate that can significantly affect the structure and function of RNA and plays an important role in biological systems[1]. During the in vitro mRNA synthesis process, 5-methyl-UTP can be incorporated into RNA molecules containing methylated uracil[2-3]. 5-methyl-UTP-mediated Methylation modification can enhance the stability and translation efficiency of RNA, reduce RNA degradation, thereby increasing the persistence and effectiveness of gene expression, and shows broad application prospects in the development of new RNA therapies and treatment methods[4]. The application of 5-methyl-UTP is crucial for studying the role of RNA methylation in gene regulation as well as the chemical properties and biological functions of RNA, 5-methyl-UT can be used in the screening of specific hydrolases and research related to nucleotide metabolism[5].
References:
[1] Gao S, Sun Y, Chen X, et al. Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA[J]. Nucleic Acids Research, 2023, 51(14): 7451-7464.
[2] NAKAYAMA C, SANEYOSHI M. Utilizations of various uridine 5′-triphosphate analogues by DNA-dependent RNA polymerases I and II purified from liver nuclei of the cherry salmon (Oncorhynchus masou)[J]. The Journal of Biochemistry, 1984, 96(5): 1501-1509.
[3] Nakayama C, Saneyoshi M. Utilization of 5-alkyl UTPs by DNA-dependent RNA polymerase I and II purified from cherry salmon (Onchorhynchus masou) liver[C]//Nucleic Acids Symposium Series. 1980 (8): s193-6.
[4] Meneghesso S, Vanderlinden E, Stevaert A, et al. Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus[J]. Antiviral research, 2012, 94(1): 35-43.
[5]Xu W L, Shen J Y, Dunn C A, et al. A new subfamily of the Nudix hydrolase superfamily active on 5-methyl-UTP (ribo-TTP) and UTP[J]. Journal of Biological Chemistry, 2003, 278(39): 37492-37496.
| Cas No. | SDF | ||
| Formula | C10H17N2O15P3 (free acid) | M.Wt | 498.2 (free acid) |
| Solubility | Storage | Store at -20°C or below | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0072 mL | 10.0361 mL | 20.0723 mL |
| 5 mM | 401.4 μL | 2.0072 mL | 4.0145 mL |
| 10 mM | 200.7 μL | 1.0036 mL | 2.0072 mL |
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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