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6-Formylpterin (Synonyms: 2-Amino-6-formylpteridin-4-one, 6-FP, Pterin-6-aldehyde)

Catalog No.GC42578

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.

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6-Formylpterin Chemical Structure

Cas No.: 712-30-1

Size Price Stock Qty
500μg
$111.00
In stock
1mg
$213.00
In stock
5mg
$891.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in "hetero-substrate" inhibition at nanomolar concentrations. However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO. In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.

Chemical Properties

Cas No. 712-30-1 SDF
Synonyms 2-Amino-6-formylpteridin-4-one, 6-FP, Pterin-6-aldehyde
Canonical SMILES O=C1C2=C(N=CC(C=O)=N2)N=C(N)N1
Formula C7H5N5O2 M.Wt 191.1
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.2329 mL 26.1643 mL 52.3286 mL
5 mM 1.0466 mL 5.2329 mL 10.4657 mL
10 mM 0.5233 mL 2.6164 mL 5.2329 mL
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Review for 6-Formylpterin

Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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