6-Methylmercaptopurine-d3 (Synonyms: 6-MMP-d3, 6-(Methylthio)purine-d3) |
| Catalog No.GC49488 |
An internal standard for the quantification of 6-MMP
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 33312-93-5
Sample solution is provided at 25 µL, 10mM.
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6-Methylmercaptopurine-d3 (6-MMP-d3) is intended for use as an internal standard for the quantification of 6-MMP by GC- or LC-MS. 6-MMP is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine .1 It is formed from 6-MP via methylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP.2
1.Rieder, M.J., and Carleton, B.Pharmacogenomics and adverse drug reactions in childrenFront. Genet.578(2014) 2.van Egmond, R., Chin, P., Zhang, M., et al.High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatmentAliment. Pharmacol. Ther.35(10)1181-1189(2012)
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