7-Ketodeoxycholic acid (Synonyms: 5β-Cholanic Acid-3α,12α-diol-7-one, 7-keto DCA) |
| Catalog No.GC55814 |
7-Ketodeoxycholic acid is a bile acid derivative that is a metabolite of bile acid in Clostridium absonum. It can also be converted by Lactobacillus and Bifidobacterium under certain conditions.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 911-40-0
Sample solution is provided at 25 µL, 10mM.
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7-Ketodeoxycholic acid is a bile acid derivative that is a metabolite of bile acid in Clostridium absonum. It can also be converted by Lactobacillus and Bifidobacterium under certain conditions[1, 2]. Bile acids are natural steroid amphiphilic compounds formed by cholesterol oxidation in the liver and play a vital role in regulating lipid metabolism[3]. 7-Ketodeoxycholic acid levels are increased in the liver tissue of ethanol-induced alcoholic liver disease (ALD) mice[4]. Patients with non-alcoholic steatohepatitis (NASH) have higher levels of 7-Ketodeoxycholic acid in their plasma[5]. Resistant starch (LRS) can promote the excretion of 7-Ketodeoxycholic acid in hyperlipidemic rats[6].
References:
[1] Sutherland J D, Macdonald I A. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum[J]. Journal of lipid research, 1982, 23(5): 726-732.
[2] Takahashi T, Morotomi M. Absence of cholic acid 7α-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium[J]. Journal of Dairy Science, 1994, 77(11): 3275-3286.
[3] Li T, Chiang J Y L. Regulation of bile acid and cholesterol metabolism by PPARs[J]. PPAR research, 2009, 2009(1): 501739.
[4] Charkoftaki G, Tan W Y, Berrios-Carcamo P, et al. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice[J]. 2022.
[5] Nimer N. Mass Spectrometry as Discovery Platform for Candidate Metabolite of Non-Alcoholic Steatohepatitis (NASH)[D]. Cleveland State University, 2020.
[6] Lei S, Liu L, Yue P, et al. Lotus seed resistant starch decreases the blood lipid and regulates the serum bile acids profiles in hyperlipidemic rats[J]. Journal of Functional Foods, 2022, 92: 105040.
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