8-Azaadenosine (Synonyms: NSC 72961) |
| Catalog No.GC50588 |
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10299-44-2
Sample solution is provided at 25 µL, 10mM.
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ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.
Zipeto et al (2016) ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 19 177 PMID:27292188 |Zhang and Slack et al (2016) ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 19 141 PMID:27494666
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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