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α-Carotene (Synonyms: all-trans-α-Carotene)

Catalog No.GC41183

α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables.

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α-Carotene Chemical Structure

Cas No.: 7488-99-5

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500μg
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1mg
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5mg
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10mg
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Sample solution is provided at 25 µL, 10mM.

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Background

α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables.[1] It inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene and halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc.[2]  It is also more potent than β-carotene in mouse models of skin and lung carcinogenesis and decreases the number of hepatomas in mice with spontaneous liver carcinogenesis when administered in drinking water at a concentration of 0.05%. [3] α-Carotene levels are increased in patients with coronary heart disease and are inversely correlated with the risk of estrogen receptor-negative breast cancer.[4][5]

Reference:
[1]. Bushway, R.J., and Wilson, A.M. Determination of α- and β-carotene in fruit and vegetables by high performance liquid chromatography. Can. Inst. Food Sci. Technol. J. 15(3), 165-169 (1982).
[2]. Murakoshi, M., Takayusa, J., Kimura, O., et al. Inhibitory effects of α-carotene on proliferation of the human neuroblastoma cell line GOTO. J. Natl. Cancer Inst. 81(21), 1649-1652 (1989).
[3]. Murakoshi, M., Nishino, H., Satomi, Y., et al. Potent preventive action of α-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by α-carotene than by β-carotene. Cancer Res. 52(23), 6583-6587 (1992).
[4]. Kontush, A., Spranger, T., Reich, A., et al. Lipophilic antioxidants in blood plasma as markers of atherosclerosis: The role of α-carotene and γ-tocopherol. Atherosclerosis 144(1), 117-122 (1999).
[5]. Zhang, X., Spiegelman, D., Baglietto, L., et al. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: A pooled analysis of 18 prospective cohort studies. Am. J. Clin. Nutr. 95(3), 713-725 (2012).

Chemical Properties

Cas No. 7488-99-5 SDF
Synonyms all-trans-α-Carotene
Chemical Name (6'R)-β,ε-carotene
Canonical SMILES CC1(C)[C@@H](/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)=CCC1
Formula C40H56 M.Wt 536.9
Solubility DMF: 0.1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml Storage Store at -20°C, protect from light, stored under nitrogen
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.8625 mL 9.3127 mL 18.6254 mL
5 mM 0.3725 mL 1.8625 mL 3.7251 mL
10 mM 0.1863 mL 0.9313 mL 1.8625 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 19 reference(s) in Google Scholar.)

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