α-D-Glucose-1,6-bisphosphate (cyclohexyl ammonium salt hydrate) (Synonyms: D-Glucose-1,6-diphosphate Glc-1,6-P2) |
| Catalog No.GC45201 |
α-D-Glucose-1,6-biphosphate is a derivative of glucose used to study carbohydrate metabolism, particularly in the identification, differentiation, and characterization of α-phosphoglucomutase, β-phosphoglucomutase, and α- and β-hexoglucomutases.
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Cas No.: 71662-13-0
Sample solution is provided at 25 µL, 10mM.
α-D-Glucose-1,6-bisphosphate is a bis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.[1] It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.[2] It is also a cofactor for the bacterial enzyme phosphopentomutase.[3],[4] α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism.
Reference:
[1]. Beitner, R. Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate. Int. J. Biochem. 22(6), 553-557 (1990).
[2]. Maliekal, P., Sokolova, T., Vertommen, D., et al. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the α-D-phosphohexomutase family. J. Biol. Chem. 282(44), 31844-31851 (2007).
[3]. Moustafa, H.M.A., Zaghloul, T.I., and Zhang, Y.-H.P. A simple assay for determining activities of phosphopentomutase from a hyperthermophilic bacterium Thermotoga maritima. Anal. Biochem. 501, 75-81 (2016).
[4]. Panosian, T.D., Nannemann, D.P., Watkins, G.R., et al. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. J. Biol. Chem. 286(10), 8043-8054 (2011).
[1]. Beitner, R. Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate. Int. J. Biochem. 22(6), 553-557 (1990).
[2]. Maliekal, P., Sokolova, T., Vertommen, D., et al. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the α-D-phosphohexomutase family. J. Biol. Chem. 282(44), 31844-31851 (2007).
[3]. Moustafa, H.M.A., Zaghloul, T.I., and Zhang, Y.-H.P. A simple assay for determining activities of phosphopentomutase from a hyperthermophilic bacterium Thermotoga maritima. Anal. Biochem. 501, 75-81 (2016).
[4]. Panosian, T.D., Nannemann, D.P., Watkins, G.R., et al. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. J. Biol. Chem. 286(10), 8043-8054 (2011).
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