A 410099.1 |
| Catalog No.GC50465 |
High affinity XIAP antagonist; active in vivo
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 762274-58-8
Sample solution is provided at 25 µL, 10mM.
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High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID:15317454 |Loeder et al (2009) A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res. 69 8977 PMID:19920200
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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