A 68930 hydrochloride |
| Catalog No.GC15498 |
Agonist of D1-like dopamine receptor,potent and selective
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130465-39-3
Sample solution is provided at 25 µL, 10mM.
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A 68930 hydrochloride is a potent and selective agonist of D1 dopamine receptor with EC50 values of 2.5 and 3920 nM for D1 and D2 receptors, respectively [1].
D1 dopamine receptor is a G-protein couple receptor for dopamine and stimulates adenylate cyclase and cyclic AMP-dependent protein kinases. D1 dopamine receptor plays an important role in behavioral responses and neuronal growth and development.
A 68930 hydrochloride is a potent and selective D1 dopamine receptor agonist. In rats, A 68930 (0.9-15.0 μM) induced hypothermia in a dose-dependent way. Also, A 68930 (0.9-15.0 μM) inhibited locomotor activity in a dose-dependent way [2]. In adult rat, A 68930 (0.0625-4.0 mg/kg) induced grooming, vacuous chewing and sniffing, which were inhibited by SCH 23390, a D1-like receptor antagonist [3]. In chronic unpredictable (CUS) stress rat models, A68930 (0.25 mg/kg) significantly normalized the reduction of the number of tyrosine hydroxylase (TH) immunoreactive neurons in the striatum, ventral tegmental area, medial forebrain bundle and substansia nigra and glucocorticoid receptor (GR) in the cortex, hippocampus and striatum. Also, A68930 normalized the antioxidant enzyme activities, increased glutathione (GSH) and inhibited lipid peroxidation [4].
References:
[1]. Kebabian JW, Briggs C, Britton DR, et al. A68930: a potent and specific agonist for the D-1 dopamine receptor. Am J Hypertens, 1990, 3(6 Pt 2): 40S-42S.
[2]. Salmi P. Independent roles of dopamine D1 and D2/3 receptors in rat thermoregulation. Brain Res, 1998, 781(1-2): 188-193.
[3]. Deveney AM, Waddington JL. Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists. Pharmacol Biochem Behav, 1997, 58(2): 551-558.
[4]. Rasheed N, Ahmad A, Al-Sheeha M, et al. Neuroprotective and anti-stress effect of A68930 in acute and chronic unpredictable stress model in rats. Neurosci Lett, 2011, 504(2): 151-155.
| Cas No. | 130465-39-3 | SDF | |
| Chemical Name | (1R,3S)-1-(aminomethyl)-3-phenylisochroman-5,6-diol hydrochloride | ||
| Canonical SMILES | OC(C1=C(C=C2)[C@H](CN)O[C@H](C3=CC=CC=C3)C1)=C2O.Cl | ||
| Formula | C16H17NO3.HCl | M.Wt | 307.78 |
| Solubility | <15.39mg/ml in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2491 mL | 16.2454 mL | 32.4907 mL |
| 5 mM | 0.6498 mL | 3.2491 mL | 6.4981 mL |
| 10 mM | 0.3249 mL | 1.6245 mL | 3.2491 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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