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Ac-Endothelin-1 (16-21), human

Catalog No.: GP10121

ETA/ETB agonist,vasoconstrictor

Ac-Endothelin-1 (16-21), human Chemical Structure

Size Price Stock Qty
1mg
$22.00
In stock
5mg
$65.00
In stock
10mg
$110.00
In stock
25mg
$154.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues, including the heart, the kidney, and the central nervous system.
At the cellular level, the effects of ET-1 appear to be mediated by two specific receptor subtypes termed ETA and ETB, both of which are functionally coupled to phospholipase C (PLC).
The C-terminal fragment , which is a highly conserved sequence in the peptides of the ET family, has been shown to discriminate between the two ET receptor subtypes termed ETA and ETB since it activates only the latter ones.

References:
1. Rubanyi, G. M., and M. A. Polokoff. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46: 325–415, 1994
2. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375–411.
3. PM Vanhoutte Endothelin-1. A matter of life and breath, Nature, 368 (1994), pp. 693–694

Chemical Properties

Cas No. N/A SDF
Synonyms Ac-His-Leu-Asp-Ile-Ile-Trp-OH
Chemical Name N/A
Canonical SMILES O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](C)CC)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CC1=CC(C=CC=C2)=C2N1)C(O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)NC(C)=O
Formula C41H59N9O10 M.Wt 837.96
Solubility ≥ 83.8mg/mL in DMSO with gentle warming Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Review for Ac-Endothelin-1 (16-21), human

Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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