β-acetyl-Boswellic Acid (Synonyms: ABA,3-O-acetyl-β-Boswellic acid,β-Boswellic acid acetate) |
| Catalog No.GC15961 |
β-acetyl-Boswellic Acid is a boswellic acid isolated from Boswellia serrata gum resin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5968-70-7
Sample solution is provided at 25 µL, 10mM.
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β-acetyl-Boswellic Acid is a specific, nonreducing-type inhibitor of the 5-LO product formation with selectivity over 12-LO and COX [1][2].
5-lipoxygenase (5-LO) is a member of the lipoxygenase family of enzymes and transforms EFA substrates into leukotrienes.
In rat peritoneal neutrophils, boswellic acids concentration dependently decreased the formation of leukotriene B4 from endogenous arachidonic acid. In isolated human platelets, boswellic acids in concentrations up to 400 μM did not impair the cyclooxygenase and 12-lipoxygenase [1]. In calcium/calcium ionophore-stimulated peritoneal neutrophils of rats, boswellic acids significantly decreased production of LTB4 and total 5-lipoxygenase products with EC50 value of about 30 μg/ml [2]. In six human myeloid leukemia cell lines, boswellic acid acetate, a 1:1 mixture of α-boswellic acid acetate and β-boswellic acid acetate induces apoptosis through caspase-mediated pathways [4].
Boswellic acids are pentacyclic triterpenes with putative anti-inflammatory effects. In a mouse model of osteoarthritis (OA), boswellic acid significantly attenuated articular cartilage erosion and significantly reduced knee synovitis and osteophyte formation. In synovium of mice, boswellic acid directly inhibit IL-1β and TLR4 induced inflammatory cytokines production [3].
References:
[1]. Safayhi H, Mack T, Sabieraj J, et al. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
[2]. Ammon HP, Safayhi H, Mack T, et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
[3]. Wang Q, Pan X, Wong HH, et al. Oral and topical boswellic acid attenuates mouse osteoarthritis. Osteoarthritis Cartilage. 2014 Jan;22(1):128-32.
[4]. Xia L, Chen D, Han R, et al. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol Cancer Ther. 2005 Mar;4(3):381-8.
| Cas No. | 5968-70-7 | SDF | |
| Synonyms | ABA,3-O-acetyl-β-Boswellic acid,β-Boswellic acid acetate | ||
| Chemical Name | (3α,4β)-3-(acetyloxy)-urs-12-en-23-oic acid | ||
| Canonical SMILES | C[C@]1(C(O)=O)[C@H](OC(C)=O)CC[C@]2(C)[C@@]3([H])CC=C4[C@](CC[C@]5(C)[C@@]4([H])[C@@H](C)[C@H](C)CC5)(C)[C@]3(C)CC[C@]21[H] | ||
| Formula | C32H50O4 | M.Wt | 498.7 |
| Solubility | ≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0052 mL | 10.0261 mL | 20.0521 mL |
| 5 mM | 0.401 mL | 2.0052 mL | 4.0104 mL |
| 10 mM | 0.2005 mL | 1.0026 mL | 2.0052 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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