ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) (Synonyms: Adrenocorticotropic Hormone (1-10), Corticotropin (1-10)) |
| Catalog No.GC42713 |
Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. The amino acid sequence of ACTH (1-10) is common to ACTH and α-melanocyte stimulating hormone. ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM). It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 μg, respectively. Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.
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