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Adapalene sodium salt

Catalog No.GC14379

Retinoic acid receptor agonist

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Adapalene sodium salt Chemical Structure

Cas No.: 911110-93-5

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10mM (in 1mL DMSO)
$38.00
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50mg
$37.00
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100mg
$57.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene sodium salt is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene sodium salt is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene sodium salt group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher than adapalene sodium salt and controls (P < 0.05). Adapalene sodium salt was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].Clinical indications: Acne; Purpura; SunburnFDA Approved Date: 1996Toxicity: Skin redness; dryness; itching; scaling; mild burning

References:
[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7.
[2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.

Chemical Properties

Cas No. 911110-93-5 SDF
Chemical Name sodium 6-(3-((3r,5r,7r)-adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate
Canonical SMILES COC1=C(C23C[C@@]4([H])C[C@](C2)([H])C[C@](C3)([H])C4)C=C(C5=CC=C6C=C(C([O-])=O)C=CC6=C5)C=C1.[Na+]
Formula C28H27NaO3 M.Wt 434.5
Solubility ≥ 4.35mg/mL in DMSO with gentle warming Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3015 mL 11.5075 mL 23.015 mL
5 mM 0.4603 mL 2.3015 mL 4.603 mL
10 mM 0.2301 mL 1.1507 mL 2.3015 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 23 reference(s) in Google Scholar.)

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