AKT Kinase Inhibitor |
| Catalog No.GC16366 |
AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 842148-40-7
Sample solution is provided at 25 µL, 10mM.
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AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].
References:
[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.
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