[Ala17]-MCH (trifluoroacetate salt) (Synonyms: Ala17-Melanin-Concentrating Hormone)

Name: [Ala17]-MCH (trifluoroacetate salt)
Brand: GlpBio
SKU: GC52414
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC52414

An MCH-derived peptide and MCH receptor agonist

Products are for research use only. Not for human use. We do not sell to patients.

[Ala17]-MCH (trifluoroacetate salt) Chemical Structure

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1 mg	$39.00	In stock
5 mg	$154.00	In stock
10 mg	$270.00	In stock
25 mg	$578.00	In stock

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >98.00%

[Ala¹⁷]-MCH is a synthetic peptide derived from the hypothalamic neuropeptide hormone melanin-concentrating hormone (MCH) and an MCH receptor agonist.¹ It binds to MCH₁ and MCH₂ receptors in CHO cells expressing the human receptors (IC₅₀s = 0.15 and 3.5 nM, respectively) and induces calcium mobilization in HEK293 cells expressing the human receptors (EC₅₀s = 17 and 54 nM, respectively).

1.Bednarek, M.A., Feighner, S.D., Hreniuk, D.L., et al.Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2Biochemistry40(31)9379-9386(2001)

Cas No.		SDF	Download SDF
Synonyms	Ala17-Melanin-Concentrating Hormone
Canonical SMILES	O=C(O)C[C@H](N[H])C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@H](N1)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)C)=O)C(N[C@@H](CCSC)C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C1=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC4=CC=CC=C4)=O.FC(F)(C(O)=O)F
Formula	C97H155N29O26S4 ? XCF3COOH	M.Wt	2271.7
Solubility	Water: 2 mg/ml	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.4402 mL	2.201 mL	4.402 mL
	5 mM	0.088 mL	0.4402 mL	0.8804 mL
	10 mM	0.044 mL	0.2201 mL	0.4402 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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[Ala17]-MCH (trifluoroacetate salt) (Synonyms: Ala17-Melanin-Concentrating Hormone)

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