all-trans-4-hydroxy Retinoic Acid (Synonyms: 4-OH-atRA, 4-hydroxy RA) |
| Catalog No.GC18539 |
all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66592-72-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM).
Review for all-trans-4-hydroxy Retinoic Acid
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
Review for all-trans-4-hydroxy Retinoic Acid
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *