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Amezinium methylsulfate (Amezinium metilsulfate) Catalog No.GC32516

Size Price Stock Qty
10mM*1mLinDMSO
$49.00
In stock
100mg
$45.00
In stock
500mg
$71.00
In stock
1g
$98.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Amezinium methylsulfate (Amezinium metilsulfate) Dilution Calculator

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Amezinium methylsulfate (Amezinium metilsulfate) Molarity Calculator

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Chemical Properties

Cas No. 30578-37-1 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES COC1=CC(N)=CN=[N+]1C2=CC=CC=C2.O=S(OC)([O-])=O
Formula C12H15N3O5S M.Wt 313.33
Solubility DMSO : ≥ 34 mg/mL (108.51 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptorsAmezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia.

[1]. Schaps D, et al. Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9.