AMPR-22 (trifluoroacetate salt) (Synonyms: KKMMKKGGKFGTFMAIGGIR)

Name: AMPR-22 (trifluoroacetate salt)
Brand: GlpBio
SKU: GC52406
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC52406

An antimicrobial peptide

Products are for research use only. Not for human use. We do not sell to patients.

AMPR-22 (trifluoroacetate salt) Chemical Structure

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5 mg	$153.00	In stock
10 mg	$274.00	In stock
25 mg	$610.00	In stock
50 mg	$916.00	In stock

Tel：(909) 407-4943 Email: sales@glpbio.com

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >95.00%

AMPR-22 is a synthetic antimicrobial peptide derived from the mitochondrial cation channel reactive oxygen species (ROS) modulator 1 (Romo1).¹ It is active against S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and carbapenem-resistant P. aeruginosa with minimum bactericidal concentration (MBC) values of 2, 2, 2, and 4 µg/ml, respectively. AMPR-22 induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa in a concentration-dependent manner. It increases survival in a mouse model of sepsis induced by S. aureus when administered at a dose of 10 mg/kg.

1.You, D.-G., Lee, H.-R., Kim, H.-K., et al.A novel peptide derived from the transmembrane domain of Romo1 is a promising candidate for sepsis treatment and multidrug-resistant bacteriaInt. J. Mol. Sci.22(15)8243(2021)

Cas No.		SDF	Download SDF
Synonyms	KKMMKKGGKFGTFMAIGGIR
Canonical SMILES	OC(C(F)(F)F)=O.O=C(N[C@@H](CCCCN[H])C(N[C@@H](CCSC)C(N[C@@H](CCSC)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(NCC(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@@](C(NCC(NCC(N[C@@](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)([H])[C@@H](C)CC)=O)C)=O)=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN[H])N[H]
Formula	C98H168N28O22S3 ? XCF3COOH	M.Wt	2186.8
Solubility	DMF: Slightly soluble,DMSO: 11 mg/mL	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.4573 mL	2.2864 mL	4.5729 mL
	5 mM	0.0915 mL	0.4573 mL	0.9146 mL
	10 mM	0.0457 mL	0.2286 mL	0.4573 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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AMPR-22 (trifluoroacetate salt) (Synonyms: KKMMKKGGKFGTFMAIGGIR)

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