Amylin (human) (trifluoroacetate salt) (Synonyms: IAPP (human), Islet Amyloid Polypeptide (human)) |
| Catalog No.GC42796 |
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cross-β arrangement of β-strands similar to amyloid-β (1-40) and amyloid-β (1-42) fibrils., Aggregated amylin (60 μM) decreases the viability of primary pancreatic islet cell cultures by 60%. It also inhibits electrically-stimulated contractions of guinea pig vas deferens (EC50 = 213 nM).
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