Home>>Signaling Pathways>> Neuroscience>> nAChR>>Anabasine ((S)-Anabasine)
Anabasine ((S)-Anabasine) Catalog No.GC30866

Size Price Stock Qty
10mM*1mLinDMSO
$61.00
In stock
10mg
$56.00
In stock
25mg
$82.00
In stock
50mg
$147.00
In stock
100mg
$258.00
In stock

Customer Review

Based on customer reviews.

Tel: (626) 353-8530 Email: sales@glpbio.com

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

View current batch:

Protocol

Animal experiment:

Adult (age range 4 to 16 months) female Sprague-Dawley rats are used in this study. One group of rats (N=12) is trained on the radial arm maze test of working and reference memory and undergo tests of an acute dose-response of Anabasine (0.02, 0.2, 1 and 2 mg/kg). Then, two doses of Anabasine (0.2 and 2 mg/kg) are tested alone or in combination with the glutamate NMDA antagonist dizocilpine (0.05 mg/kg). The saline vehicle is used as vehicle control and dizocilpine alone is used as an impaired control. All conditions are given to each rat in a repeated measures counterbalanced design[1].

References:

[1]. Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28(10):915-22.

Chemical Properties

Cas No. 494-52-0 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES C1([C@H]2NCCCC2)=CC=CN=C1
Formula C10H14N2 M.Wt 162.23
Solubility DMSO : 100 mg/mL (616.41 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

Background

Anabasine is a nicotinic receptor agonist.

Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8)[1].

[1]. Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28(10):915-22.