Angiotensin A (trifluoroacetate salt) (Synonyms: Ala-Arg-Val-Tyr-Ile-His-Pro-Phe, DesAsp1-Ala1-Ang II) |
Catalog No.GC52415 |
An AT1 and AT2 receptor agonist and active metabolite of angiotensin II
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Angiotensin A is an angiotensin II type 1 (AT1) and AT2 receptor agonist and active metabolite of the peptide hormone angiotensin II .1 It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC50 = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by the AT1 antagonist EXP-3174 . The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.1,2
1.Jankowski, V., Vanholder, R., van der Giet, M., et al.Mass-spectrometric identification of a novel angiotensin peptide in human plasmaArterioscler. Thromb. Vasc. Biol.27(2)297-302(2007) 2.Sandoval, J., Del Valle-MondragÓn, L., Masso, F., et al.Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertensionEur. Respir. J.56(1)1902416(2020)
Cas No. | SDF | Download SDF | |
Synonyms | Ala-Arg-Val-Tyr-Ile-His-Pro-Phe, DesAsp1-Ala1-Ang II | ||
Canonical SMILES | OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](N)C)=O)CCCNC(N)=N)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CCC3)=O)=O)=O.OC(C(F)(F)F)=O | ||
Formula | C49H71N13O10 ? XCF3COOH | M.Wt | 1002.2 |
Solubility | DMSO: 5 mg/ml,PBS (pH 7.2): 5 mg/ml | Storage | -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.9978 mL | 4.989 mL | 9.978 mL |
5 mM | 0.1996 mL | 0.9978 mL | 1.9956 mL |
10 mM | 0.0998 mL | 0.4989 mL | 0.9978 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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