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Angiotensin A (trifluoroacetate salt) (Synonyms: Ala-Arg-Val-Tyr-Ile-His-Pro-Phe, DesAsp1-Ala1-Ang II)

Catalog No.GC52415

An AT1 and AT2 receptor agonist and active metabolite of angiotensin II

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Angiotensin A (trifluoroacetate salt) Chemical Structure

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5 mg
$136.00
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10 mg
$258.00
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25 mg
$610.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Angiotensin A is an angiotensin II type 1 (AT1) and AT2 receptor agonist and active metabolite of the peptide hormone angiotensin II .1 It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC50 = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by the AT1 antagonist EXP-3174 . The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.1,2

1.Jankowski, V., Vanholder, R., van der Giet, M., et al.Mass-spectrometric identification of a novel angiotensin peptide in human plasmaArterioscler. Thromb. Vasc. Biol.27(2)297-302(2007) 2.Sandoval, J., Del Valle-MondragÓn, L., Masso, F., et al.Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertensionEur. Respir. J.56(1)1902416(2020)

Chemical Properties

Cas No. SDF Download SDF
Synonyms Ala-Arg-Val-Tyr-Ile-His-Pro-Phe, DesAsp1-Ala1-Ang II
Canonical SMILES OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](N)C)=O)CCCNC(N)=N)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CCC3)=O)=O)=O.OC(C(F)(F)F)=O
Formula C49H71N13O10 ? XCF3COOH M.Wt 1002.2
Solubility DMSO: 5 mg/ml,PBS (pH 7.2): 5 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9978 mL 4.989 mL 9.978 mL
5 mM 0.1996 mL 0.9978 mL 1.9956 mL
10 mM 0.0998 mL 0.4989 mL 0.9978 mL
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