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Anidulafungin

Catalog No.GC12754

Anidulafungin Chemical Structure

Antifungal drug

Size Price Stock Qty
10mM (in 1mL DMSO)
$65.00
In stock
100mg
$179.00
In stock
250mg
$341.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Protocol

Antifungal assay [1]:

Fungi

Aspergillus species

Preparation method

The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.

Reacting condition

48 hrs

Applications

Anidulafungin potently inhibited Aspergillus species, with a MEC90 value of 0.02 mg/mL. The ranges of MIC and MEC of Anidulafungin against A. fumigatus, A. flavus, A. niger, A. glaucus group and A. versicolor were 0.00125 ~ 0.005 μ g/mL and 0.005 ~ 10.24 μ g/mL, respectively.

Animal experiment [2]:

Animal models

Mice infected with strains FMR 9965, FMR 8756, FMR 9960, FMR 10084 or FMR 9966 of Aspergillus flavus

Dosage form

1, 5 or 10 mg/kg; i.p.; q.d., for 7 days

Applications

In Mice infected with strains FMR 9965, FMR 8756, FMR 9960, FMR 10084 or FMR 9966 of Aspergillus flavus, Anidulafungin at the doses of 5 and 10 mg/kg significantly prolonged survival. There were no substantial difference between the doses of 5 and 10 mg/kg. Moreover, in spleens and kidneys, Anidulafungin significantly reduced the fungal load in a dose-dependent manner. According to the bioassay results, at day 5 of treatment, the Anidulafungin serum levels were beyond the corresponding minimum effective concentrations of all strains.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Zhanel GG1, Karlowsky JA, Harding GA, Balko TV, Zelenitsky SA, Friesen M, Kabani A, Turik M, Hoban DJ. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5.

[2]. Calvo E, Pastor FJ, Mayayo E, Salas V, Guarro J. In vitro activity and in vivo efficacy of anidulafungin in murine infections by Aspergillus flavus. Antimicrob Agents Chemother. 2011 Mar;55(3):1290-2.

Background

Anidulafungin (LY-303366)is a synthetic derivative of echinocandin B, used as a drug of antifungal [1].

Anidulafungin has been reported to inhibit systemic isolates of Candida species with the MIC90 values of 0.08μg/ml, 0.32μg/ml, 0.32μg/ml and 5.12μg/ml for C.albicans (n=99), C.glabrata(n=18), C.tropicalis(n=10), and C.parapsilosis (n=10), respectively. In addition, Anidulafungin has been found to be active against Aspergillus species(n=20) with the MIC90 values of ~0.02μg/ml. Apart from these, Anidulafungin has been revealed to inactively restrain with the MIC90 values of >10.24μg/ml and 16μg/ml, for C.neoformans and B.dermatitidis, respectively [1].

References:
[1] Zhanel GG1, Karlowsky JA, Harding GA, Balko TV, Zelenitsky SA, Friesen M, Kabani A, Turik M, Hoban DJ. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5.
[2]. Locke JB, et al. Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6100-7.
 

Chemical Properties

Cas No. 166663-25-8 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O[C@H]1[C@H](C)CN(C([C@H]([C@H](C)O)NC([C@H]([C@@H]([C@@H](C(C=C2)=CC=C2O)O)O)NC([C@H](C3)N(C([C@H]([C@H](C)O)NC4=O)=O)C[C@@H]3O)=O)=O)=O)[C@@H]1C(N[C@H]([C@@H](C[C@@H]4NC(C5=CC=C(C6=CC=C(C(C=C7)=CC=C7OCCCCC)C=C6)C=C5)=O)O)O)=O
Formula C58H73N7O17 M.Wt 1140.24
Solubility ≥ 30 mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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